Abstract:
Renal failure is one of the more common medical conditions affect Sudanese
people in which renal fail to adequately filter waste product from blood that is
characterized by iron deficiency state with decrease serum iron which reflect the
amount of iron immediately available for hemoglobin and red blood cell synthesis.
Erythropoietin (EPO) is an effective but expensive treatment for anemia in patients
with chronic renal failure. This was Observational descriptive Cross sectional
facility based study aimed to evaluate iron status and responsiveness to EPO in end
stage renal disease (ESRD) patients on hemodialysis in Asbab hospital. Fifty seven
patients with ESRD were participated in this study. Data was obtained by an
interview questionnaire and laboratory investigations. EPO resistance index was
calculated as the weekly weight-adjusted dose of EPO divided by the hemoglobin
level. Iron profile indices and some plasma electrolytes were assessed by using
standard laboratory methods. More than 50% of the participants were males and
most of patients age (79%) was above 33 years old, 57.9 % of patients were
responsive and 42.1 % were non-responsive to ESA. the responsive patients
showed higher values in all electrolytes(Ca2+,K+,Na+) with exception of
phosphorus. Serum iron, TIBC, TSAT, Hb and PCV showed significant increase in
responsive patients as compared to non-responsive patients (P<0.01). Ferritin was
higher in the non-responsive patients than responsive patients. Significant association 2= 1.952, P-value= 0.162) was found between responsiveness of ESA
and number of session per week and route of administration. In conclusion, Our
findings suggested that among our study population, a significant proportion was
receiving ESA. In addition, we demonstrated that level of iron profile indices
(serum iron, TIBC and saturation) were increased significantly in responsiveness
patients as compared to non-responsive patients.
